Homozygosity disequilibrium and its gene regulation
نویسندگان
چکیده
منابع مشابه
Homozygosity disequilibrium and its gene regulation
Homozygosity disequilibrium (HD) describes a nonrandom pattern of sizable runs of homozygosity (ROH) that deviated from a random distribution of homozygotes and heterozygotes in the genome. In this study, we developed a double-weight local polynomial model for estimating homozygosity intensity. This new estimation method enables considering the local property and genetic information of homozygo...
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We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear ...
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Homozygosity-based statistics such as Ohta's identity-in-state (IIS) excess offer the potential to measure linkage disequilibrium for multiallelic loci in small samples. However, previous observations have suggested that for independent loci, in small samples these statistics might produce values that more frequently lie on one side rather than on the other side of zero. Here we investigate the...
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Homozygosity disequilibrium (HD), a nonrandom sizable run of homozygosity in the genome, may be related to the evolution of populations and may also confer susceptibility to disease. No studies have investigated HD using whole genome sequencing (WGS) analysis. In this study, we used an enhanced version of Loss-Of-Heterozygosity Analysis Suite (LOHAS) software to investigate HD through analysis ...
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Dizziness, a frequent occurrence in the elderly, carries substantial health and quality-of-life consequences for patients. Disequilibrium of the elderly refers to dizziness or ataxia (or both) without apparent localizing signs and is typically attributed to the aging process.In many cases, disequilibrium is multifactorial and worsened or triggered by multiple medications and iatrogenicity. This...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2016
ISSN: 1753-6561
DOI: 10.1186/s12919-016-0023-z